A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100 | Zendy

Y. M. Parsons | Zendy; Ruth M. Hall | Zendy; H. W. Stokes | Zendy

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A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100

Author(s) -

Y. M. Parsons,

Ruth M. Hall,

H. W. Stokes

Publication year - 1991

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.35.11.2436

Subject(s) - integron , dihydrofolate reductase , plasmid , biology , gene , genetics , sequence (biology) , trimethoprim , microbiology and biotechnology , antibiotics

A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.

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