Petite mutagenesis in Saccharomyces cerevisiae by a series of bis-cationic trypanocidal drugs | Zendy

Lynnette R. Ferguson | Zendy; Richard J. Sundberg | Zendy

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Petite mutagenesis in Saccharomyces cerevisiae by a series of bis-cationic trypanocidal drugs

Author(s) -

Lynnette R. Ferguson,

Richard J. Sundberg

Publication year - 1991

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.35.11.2318

Subject(s) - mutagenesis , saccharomyces cerevisiae , pyridinium , cationic polymerization , trypanocidal agent , chemistry , biology , biochemistry , mutation , yeast , gene , trypanosoma brucei , organic chemistry , medicinal chemistry

A group of bis-cationic imidazo[1,2-a]pyridinium salts and related compounds, some of which exhibit in vivo trypanocidal activity, have been investigated for induction of petite mutagenesis in Saccharomyces cerevisiae. All of the compounds which are active trypanocides induce mutagenesis. There appears to be a correlation between trypanocidal activity and mutagenic activity which may have its structural origin in the spatial separation of the cationic centers.

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