Prospective study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery | Zendy

Gaetano Pierpaolo Privitera | Zendy; Paolo Scarpellini | Zendy; G Ortisi | Zendy; Gianlucca Gonçalves Nicastro | Zendy; Roberto Nicolin | Zendy; Fausto de Lalla | Zendy

Open Access

Prospective study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery

Author(s) -

Gaetano Pierpaolo Privitera,

Paolo Scarpellini,

G Ortisi,

Gianlucca Gonçalves Nicastro,

Roberto Nicolin,

Fausto de Lalla

Publication year - 1991

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.35.1.208

Subject(s) - mezlocillin , cefoxitin , medicine , cefotetan , cefazolin , clostridium difficile , cephalosporin , cefoperazone , antibiotics , ceftriaxone , surgery , diarrhea , antibiotic associated diarrhea , gastroenterology , microbiology and biotechnology , piperacillin , staphylococcus aureus , imipenem , antibiotic resistance , genetics , bacteria , pseudomonas aeruginosa , biology

A total of 108 volunteers undergoing an elective surgical procedure were randomly given a single 2-g intravenous prophylactic dose of either a cephalosporin or mezlocillin. Stool samples were cultured for Clostridium difficile the day before the operation and later on postoperative days 4, 7, and 14. C. difficile was detected in 23.0% of patients who received a cephalosporin (cefoxitin, 8.3%; cefazolin, 14.3%; cefotetan, 20.0%; ceftriaxone, 25.0%; cefoperazone, 43.7%), in 3.3% of patients given mezlocillin, and in none of 15 control volunteers given no antimicrobial agent. No patient experienced diarrhea.

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