In vitro activities of 4-quinolones against the fish pathogen Aeromonas salmonicida | Zendy

Andrew C. Barnes | Zendy; C. S. Lewin | Zendy; T. S. Hastings | Zendy; S. G. B. Amyes | Zendy

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In vitro activities of 4-quinolones against the fish pathogen Aeromonas salmonicida

Author(s) -

Andrew C. Barnes,

C. S. Lewin,

T. S. Hastings,

S. G. B. Amyes

Publication year - 1990

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.34.9.1819

Subject(s) - aeromonas salmonicida , oxolinic acid , enrofloxacin , pathogen , microbiology and biotechnology , aeromonas , antibiotics , biology , antibacterial agent , aeromonas hydrophila , chemistry , fish <actinopterygii> , bacteria , antibiotic resistance , fishery , nalidixic acid , ciprofloxacin , genetics

The activities of five fluorinated 4-quinolones, namely, sarafloxacin, enrofloxacin, PD127391, PD117596, and CI934, against the fish pathogen Aeromonas salmonicida were investigated and compared with that of oxolinic acid. The results indicated that with the exception of CI934, these drugs are more active than oxolinic acid in terms of MIC. No inoculum effect was observed, but the drugs were less active at 10 degrees C than at 22 degrees C. The presence of 3% of NaCl caused an increase in drug activity. Resistance to the drugs appeared to be fairly stable, with only a small decrease in activity after 10 successive passages of the test strains on drug-free tryptone soya agar.

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