Open AccessAntistaphylococcal activity of pentamidine
Author(s) -
Michael Libman,
Mark A. Miller,
Geoffrey K. Richards
Publication year - 1990
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.34.9.1795
Subject(s) - microbiology and biotechnology , staphylococcus aureus , staphylococcus epidermidis , candida albicans , pentamidine , streptococcus pyogenes , micrococcus , staphylococcus , micrococcaceae , streptococcus , biology , chemistry , antibiotics , bacteria , antibacterial agent , medicine , pneumonia , genetics
Pentamidine isethionate was bacteriostatic against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus sanguis, Micrococcus sp., and Candida albicans. S. aureus was inhibited by concentrations of 16 to 64 micrograms/ml and killed by 64 to greater than or equal to 128 micrograms/ml. Staphylococcal killing was consistently greater in the presence of cations and was unaffected by methicillin resistance.