Antibacterial activity of lomefloxacin in a pharmacokinetic in vitro model | Zendy

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Antibacterial activity of lomefloxacin in a pharmacokinetic in vitro model

Author(s) -

C Rustige,

B. Wiedemann

Publication year - 1990

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.34.6.1107

Subject(s) - lomefloxacin , enterococcus faecalis , pseudomonas aeruginosa , pharmacokinetics , microbiology and biotechnology , staphylococcus aureus , antibacterial activity , antibacterial agent , bacteria , chemistry , in vitro , enterococcus , minimum inhibitory concentration , antibiotics , norfloxacin , biology , pharmacology , ciprofloxacin , biochemistry , genetics

An in vitro model simulating two-compartment pharmacokinetics was used to study the antibacterial activity of lomefloxacin after single oral doses of 200 and 400 mg. Lomefloxacin produced reliable bactericidal activity against gram-negative aerobic bacteria and staphylococci. Bacterial strains for which MICs were less than 0.5 microgram/ml were inhibited with both dosing schedules. Doubling the dose from 200 to 400 mg increased the bactericidal activity only against Pseudomonas aeruginosa. Against Enterococcus faecalis lomefloxacin showed no effect. Selection of resistant variants during the simulation of treatment was observed with Staphylococcus aureus and P. aeruginosa.

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