Antifungal activity in human cerebrospinal fluid and plasma after intravenous administration of Allium sativum | Zendy

L. E. Davis | Zendy; Jinkun Shen | Zendy; Yongyang Cai | Zendy

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Antifungal activity in human cerebrospinal fluid and plasma after intravenous administration of Allium sativum

Author(s) -

L. E. Davis,

Jinkun Shen,

Yongyang Cai

Publication year - 1990

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.34.4.651

Subject(s) - allium sativum , cerebrospinal fluid , cryptococcus neoformans , meningitis , titer , cryptococcus , antifungal , cryptococcosis , microbiology and biotechnology , medicine , pharmacology , biology , immunology , antibody , surgery , botany

Commercial Allium sativum (garlic) extract was given intravenously to two patients with cryptococcal meningitis and three patients with other types of meningitis. Plasma titers of anti-Cryptococcus neoformans activity rose twofold over preinfusion titers. Anti-C. neoformans activity was detected in four of five cerebrospinal fluid samples but not in pooled normal cerebrospinal fluid.

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