Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks | Zendy

Isabelle Fourel | Zendy; O. Hantz | Zendy; Kyoichi A. Watanabe | Zendy; Chantal Jacquet | Zendy; Bruno B. Chomel | Zendy; Jack J. Fox | Zendy; C. Trépo | Zendy

Open Access

Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks

Author(s) -

Isabelle Fourel,

O. Hantz,

Kyoichi A. Watanabe,

Chantal Jacquet,

Bruno B. Chomel,

Jack J. Fox,

C. Trépo

Publication year - 1990

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.34.3.473

Subject(s) - woodchuck hepatitis virus , virology , viral replication , virus , biology , dna polymerase , toxicity , dna synthesis , dna , microbiology and biotechnology , hepatitis b virus , hepadnaviridae , medicine , biochemistry

The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.

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