Open AccessCloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus
Author(s) -
Mirjaesin,
Pamela Svec,
James R. Lupski,
G. N. Godson,
Barry N. Kreiswirth,
John Kornblum,
Steven J. Projan
Publication year - 1990
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.34.11.2273
Subject(s) - staphylococcus aureus , tetracycline , biology , cloning (programming) , nucleic acid sequence , microbiology and biotechnology , gene , genetics , virology , antibiotics , bacteria , computer science , programming language
This report describes the cloning and sequencing of a chromosomally encoded tetracycline resistance determinant from a clinical isolate of methicillin-resistant Staphylococcus aureus. On the basis of the sequence, the gene is in the tet(M) class, and it was shown that the S. aureus tetA(M) gene is induced at the level of transcription.