In vivo selection for transmissible drug resistance in Salmonella typhi during antimicrobial therapy | Zendy

Ruth A. Schwalbe | Zendy; Charles W. Hoge | Zendy; J. Glenn Morris | Zendy; P N O'Hanlon | Zendy; Robert Crawford | Zendy; Peter H. Gilligan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

In vivo selection for transmissible drug resistance in Salmonella typhi during antimicrobial therapy

Author(s) -

Ruth A. Schwalbe,

Charles W. Hoge,

J. Glenn Morris,

P N O'Hanlon,

Robert Crawford,

Peter H. Gilligan

Publication year - 1990

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.34.1.161

Subject(s) - salmonella typhi , microbiology and biotechnology , klebsiella pneumoniae , biology , agarose gel electrophoresis , gentamicin , ampicillin , salmonella , antimicrobial , drug resistance , trimethoprim , sulfamethoxazole , virology , tetracycline , chloramphenicol , escherichia coli , antibiotics , bacteria , dna , biochemistry , genetics , gene

We report the recovery of Salmonella typhi that acquired resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and gentamicin subsequent to multiple antibiotic therapy. Escherichia coli and Klebsiella pneumoniae isolates which were recovered from the same stool sample displayed identical resistance patterns. Agarose gel electrophoresis revealed that S. typhi and laboratory-derived transconjugants contained a high-molecular-weight plasmid present in the resistant intestinal bacteria.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research