Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene
Author(s) -
Gioconda San-Blas,
Felipe San-Blas,
Francisco Javier Martín Gil,
Leonardo Mariño,
Rafael ApitzCastro
Publication year - 1989
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.33.9.1641
Subject(s) - paracoccidioides brasiliensis , dimorphic fungus , microbiology and biotechnology , biology , fungus , paracoccidioides , pathogenic fungus , pathogen , antifungal , biochemistry , yeast , botany
Ajoene, a garlic-derived compound that prevents platelet activation, inhibited the growth of Paracoccidioides brasiliensis, a fungal pathogen for humans, by affecting the integrity of the fungal cytoplasmic membrane. This action may be the basis for the study of ajoene as a possible specific antifungal drug.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom