Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir | Zendy

Donald M. Coen | Zendy; D. Goldstein | Zendy; Sandra K. Weller | Zendy

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Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir

Author(s) -

Donald M. Coen,

D. Goldstein,

Sandra K. Weller

Publication year - 1989

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.33.8.1395

Subject(s) - ribonucleotide reductase , herpes simplex virus , mutant , aphidicolin , virology , virus , biology , aciclovir , simplexvirus , herpesviridae , enzyme , biochemistry , viral disease , dna polymerase , gene , protein subunit

Two mutants defective in herpes simplex virus-encoded ribonucleotide reductase activity exhibited the novel phenotype of hypersensitivity to acyclovir, aphidicolin, and to a lesser extent, phosphonoacetic acid. These results have implications for acyclovir resistance and the development of drugs that potentiate acyclovir action by inhibition of viral ribonucleotide reductase.

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