Susceptibility of methicillin-resistant Staphylococcus aureus to the selenium-containing compound 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51) | Zendy

Ryushi Nozawa | Zendy; Takeshi Yokota | Zendy; T Fujimoto | Zendy

Open Access

Susceptibility of methicillin-resistant Staphylococcus aureus to the selenium-containing compound 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51)

Author(s) -

Ryushi Nozawa,

Takeshi Yokota,

T Fujimoto

Publication year - 1989

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.33.8.1388

Subject(s) - staphylococcus aureus , selenium , microbiology and biotechnology , micrococcaceae , enterobacteriaceae , antibacterial agent , methicillin resistant staphylococcus aureus , antibacterial activity , chemistry , biology , antibiotics , bacteria , escherichia coli , biochemistry , organic chemistry , genetics , gene

The growth of Staphylococcus aureus 209P was inhibited by 0.20 micrograms of 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51) per ml, while strains of the family Enterobacteriaceae were more resistant to the drug. The MIC for 90% of methicillin-resistant S. aureus strains was 1.56 micrograms/ml, and the drug was bactericidal. The selenium in PZ51 was essential, since its sulfur analog (PZ25) lost the antibacterial activity.

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