Open AccessPenicillin-binding protein 2 is required for induction of the Citrobacter freundii class I chromosomal beta-lactamase in Escherichia coli
Author(s) -
B Oliva,
Peter M. Bennett,
Ian Chopra
Publication year - 1989
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.33.7.1116
Subject(s) - citrobacter freundii , escherichia coli , penicillin binding proteins , citrobacter , enterobacteriaceae , mutant , penicillin , microbiology and biotechnology , biology , beta lactamase , sos response , gene , antibiotics , biochemistry
Involvement of Escherichia coli penicillin-binding proteins (PBPs) in induction of the cloned ampC Citrobacter freundii beta-lactamase by 6-aminopenicillanic acid was investigated. The enzyme was not inducible at 42 degrees C in a mutant thermosensitive for expression of PBP 2. The results imply that PBP 2 is involved in the process leading to induction of ampC.