Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet | Zendy

Rie Koshida | Zendy; Lotta Vrang | Zendy; Gustav Gilljam | Zendy; Johan Harmenberg | Zendy; B. Öberg | Zendy; Britta Wahrén | Zendy

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Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet

Author(s) -

Rie Koshida,

Lotta Vrang,

Gustav Gilljam,

Johan Harmenberg,

B. Öberg,

Britta Wahrén

Publication year - 1989

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.33.5.778

Subject(s) - foscarnet , virology , reverse transcriptase , in vitro , biology , cell culture , human immunodeficiency virus (hiv) , lentivirus , virus , reverse transcriptase inhibitor , pharmacology , sida , viral disease , biochemistry , herpesviridae , rna , genetics , gene

We describe a synergistic effect of combinations of foscarnet and 3'-azido-3'-deoxythymidine against human immunodeficiency virus type 1 multiplication in cell culture, an additive effect of foscarnet and 3'-azido-3'-deoxythymidine triphosphate against human immunodeficiency virus type 1 reverse transcriptase, and a low toxicity in cell culture of combinations of the two drugs.

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