Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection | Zendy

S.C. Harris | Zendy; Jack Wallace | Zendy; George Foulds | Zendy; Michael G. Rinaldi | Zendy

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Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection

Author(s) -

S.C. Harris,

Jack Wallace,

George Foulds,

Michael G. Rinaldi

Publication year - 1989

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.33.5.714

Subject(s) - chromatography , urine , chemistry , gas chromatography , pharmacokinetics , coefficient of variation , nitrogen , fluconazole , capillary action , cerebrospinal fluid , pharmacology , medicine , antifungal , biology , materials science , biochemistry , microbiology and biotechnology , organic chemistry , composite material

A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.

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