Frequency of in vitro resistance of Pseudomonas aeruginosa to cefepime, ceftazidime, and cefotaxime | Zendy

J Fung-Tomc | Zendy; E Huczko | Zendy; Mark S. Pearce | Zendy; R E Kessler | Zendy

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Frequency of in vitro resistance of Pseudomonas aeruginosa to cefepime, ceftazidime, and cefotaxime

Author(s) -

J Fung-Tomc,

E Huczko,

Mark S. Pearce,

R E Kessler

Publication year - 1988

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.32.9.1443

Subject(s) - cefepime , ceftazidime , cefotaxime , microbiology and biotechnology , cephalosporin , pseudomonas aeruginosa , biology , pseudomonas , antibiotics , bacteria , genetics

The selection frequencies of cefepime (BMY 28142), ceftazidime, and cefotaxime resistance among Pseudomonas aeruginosa strains were determined. Cefepime-resistant mutants were not selected by cefepime (frequency, less than 10(-11)). Ceftazidime- and cefotaxime-resistant mutants were isolated at frequencies of 10(-5) to 10(-10) and were often cross-resistant. However, cefepime resistance among ceftazidime- and cefotaxime-resistant mutants was rare. Selected mutants resistant to cefepime constitutively produced 40- to 450-fold more beta-lactamase than did the parent strain.

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