In vitro activity of U-76,252 (CS-807), a new oral cephalosporin | Zendy

Robert J. Fass | Zendy; V L Helsel | Zendy

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In vitro activity of U-76,252 (CS-807), a new oral cephalosporin

Author(s) -

Robert J. Fass,

V L Helsel

Publication year - 1988

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.32.7.1082

Subject(s) - proteus mirabilis , microbiology and biotechnology , enterococcus faecalis , citrobacter , cephalosporin , pseudomonas aeruginosa , enterobacteriaceae , enterococcus , aeromonas , haemophilus influenzae , staphylococcus aureus , aeromonas hydrophila , streptococcus agalactiae , escherichia coli , biology , streptococcus , chemistry , antibiotics , bacteria , biochemistry , genetics , gene

U-76,252 is the prodrug of U-76,253. MICs of U-76,253 were 0.015 to 0.06 microgram/ml for greater than or equal to 90% of the strains of Streptococcus spp., Haemophilus influenzae, and Proteus mirabilis; 0.25 to 1 microgram/ml for Branhamella catarrhalis, Escherichia coli, Klebsiella spp., and Citrobacter diversus; 1 to 8 micrograms/ml for Staphylococcus spp.; and 2 to greater than 16 micrograms/ml for other members of the family Enterobacteriaceae and Aeromonas hydrophila; for 72% of the latter group, MICs were less than or equal to 4 micrograms/ml. MICs for Pseudomonas aeruginosa and Enterococcus faecalis were greater than 16 micrograms/ml.

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