Open AccessTreatment of uncomplicated gonorrhea with single-dose imipenem-cilastatin
Author(s) -
Michael Verdon,
Franklyn N. Judson,
Josephine M. Ehret,
Carolyn Root,
Edward W. Hook,
William M. McCormack,
C. Francès,
K Draft,
Joseph W. Shands,
H. Hunter Handsfield
Publication year - 1988
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.32.5.773
Subject(s) - gonorrhea , cilastatin , imipenem , imipenem/cilastatin , neisseria gonorrhoeae , medicine , chlamydia trachomatis , neisseriaceae , antibiotics , microbiology and biotechnology , gynecology , virology , biology , antibiotic resistance , human immunodeficiency virus (hiv)
Single 500-mg intramuscular doses of imipenem-cilastatin cured 116 (95%) of 122 men and 9 of 9 women with uncomplicated gonorrhea due to beta-lactamase-negative Neisseria gonorrhoeae. Most co-existing Chlamydia trachomatis infections persisted. Imipenem-cilastatin is effective for uncomplicated gonorrhea in men but has no advantages over other available regimens.