Effect of oral activated charcoal on tobramycin clearance | Zendy

Robin L. Davis | Zendy; Jeffrey R. Koup | Zendy; R A Roon | Zendy; K E Opheim | Zendy; Allison Smith | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effect of oral activated charcoal on tobramycin clearance

Author(s) -

Robin L. Davis,

Jeffrey R. Koup,

R A Roon,

K E Opheim,

Allison Smith

Publication year - 1988

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.32.2.274

Subject(s) - activated charcoal , tobramycin , pharmacokinetics , aminoglycoside , charcoal , clearance , pharmacology , medicine , antibiotics , chemistry , gentamicin , urology , biochemistry , organic chemistry , adsorption

To evaluate the effect of activated charcoal on aminoglycoside pharmacokinetics, six healthy volunteers received tobramycin intravenously with and without multiple oral doses of activated charcoal. Activated charcoal did not have a statistically significant effect on any pharmacokinetic parameter. We conclude that activated charcoal does not enhance tobramycin clearance in subjects with normal renal function when concentrations in serum are within the therapeutic range.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research