Open AccessEnterohepatic circulation of NY-198, a new difluorinated quinolone, in rats
Author(s) -
Akira Saito,
Osamu Nagata,
Yuusuke Takahara,
E Okezaki,
Takehisa Yamada,
Yutaka Ito
Publication year - 1988
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.32.1.156
Subject(s) - enterohepatic circulation , glucuronide , hydrolysis , chemistry , pharmacology , metabolism , medicine , endocrinology , biology , biochemistry
Enterohepatic circulation of NY-198 in rats was studied. NY-198 glucuronide in the bile was rapidly hydrolyzed to NY-198 by the intestinal contents. Hydrolyzed and parent NY-198 in the bile were reabsorbed from the intestine. The amount of NY-198 in enterohepatic circulation was 59.8% of that excreted in the bile.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom