Open AccessAntimicrobial susceptibilities of Bordetella species isolated in a Multicenter Pertussis Surveillance Project
Author(s) -
T A Kurzynski,
D M Boehm,
J A Rott-Petri,
Ronald F. Schell,
P E Allison
Publication year - 1988
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.32.1.137
Subject(s) - roxithromycin , microbiology and biotechnology , bordetella pertussis , ofloxacin , erythromycin , norfloxacin , amoxicillin , ciprofloxacin , pefloxacin , sulfamethoxazole , enoxacin , trimethoprim , antibacterial agent , tetracycline , biology , antibiotics , bacteria , genetics
MICs for 90% (MIC90s) of 75 Bordetella pertussis strains for amoxicillin, erythromycin, rifampin, and sulfamethoxazole-trimethoprim were 1, less than or equal to 0.12, 1, and 4 micrograms/ml, respectively. Susceptibility rates were all greater than or equal to 93%. Only 17% of the strains were susceptible to tetracycline. The MIC90s of ciprofloxacin, enoxacin, norfloxacin, ofloxacin, and roxithromycin were less than or equal to 0.06, 0.5, 0.25, 0.12, and 0.5 micrograms/ml, respectively. For B. parapertussis, the MIC90s were 16-fold higher with amoxicillin and rifampin and 2- to 4-fold higher with the fluoroquinolones and roxithromycin.
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