Effect of roxithromycin on acute toxoplasmosis in mice | Zendy

Huilan Chang | Zendy; J C Pechère | Zendy

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Effect of roxithromycin on acute toxoplasmosis in mice

Author(s) -

Huilan Chang,

J C Pechère

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.7.1147

Subject(s) - roxithromycin , toxoplasmosis , toxoplasma gondii , medicine , pharmacology , immunology , biology , antibiotics , microbiology and biotechnology , antibody , erythromycin

Roxithromycin effectively treated acute peritoneal murine toxoplasmosis. After five doses, starting 24 h after challenge, the 100 and 50% survival doses were 540 and 336 mg/kg per day, respectively. After 14 doses, starting 3 h after challenge, the 50% survival dose was 360 mg/kg per day. Toxoplasma gondii was recovered from the brain in 59 and 28% of surviving mice treated with 5 and 14 doses, respectively.

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