In vitro activity of A-56268 (TE-031), a new macrolide, compared with that of erythromycin and clindamycin against selected gram-positive and gram-negative organisms | Zendy

Constance A. Benson | Zendy; John Segreti | Zendy; Fran Beaudette | Zendy; David Hines | Zendy; Larry J. Goodman | Zendy; R L Kaplan | Zendy; Gordon M. Trenholme | Zendy

Open Access

In vitro activity of A-56268 (TE-031), a new macrolide, compared with that of erythromycin and clindamycin against selected gram-positive and gram-negative organisms

Author(s) -

Constance A. Benson,

John Segreti,

Fran Beaudette,

David Hines,

Larry J. Goodman,

R L Kaplan,

Gordon M. Trenholme

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.2.328

Subject(s) - erythromycin , microbiology and biotechnology , streptococcus pyogenes , clindamycin , streptococcus pneumoniae , gram , biology , campylobacter fetus , streptococcus , listeria monocytogenes , staphylococcus aureus , antibiotics , campylobacter , bacteria , genetics

The in vitro activity of A-56268 was determined and compared with that of erythromycin and clindamycin against a limited spectrum of 401 gram-positive and gram-negative organisms. A-56268 was quite active against erythromycin-susceptible Staphylococcus aureus, Neisseria gonorrhoeae, Listeria monocytogenes, Streptococcus pneumoniae, Streptococcus pyogenes, and group B streptococci and was moderately active against Campylobacter fetus subsp. fetus. A-56268 was consistently bactericidal only for S. pneumoniae. The activity of A-56268 was comparable to that of erythromycin against most organisms tested.

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