Pharmacokinetics and tissue penetration of Ro 23-6240, a new trifluoroquinolone | Zendy

Robert A. Wise | Zendy; B. Kirkpatrick | Zendy; J. P. Ashby | Zendy; D. J. Griggs | Zendy

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Pharmacokinetics and tissue penetration of Ro 23-6240, a new trifluoroquinolone

Author(s) -

Robert A. Wise,

B. Kirkpatrick,

J. P. Ashby,

D. J. Griggs

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.2.161

Subject(s) - pharmacokinetics , cantharidin , pharmacology , penetration (warfare) , serum concentration , absorption (acoustics) , half life , medicine , chemistry , materials science , organic chemistry , composite material , operations research , engineering

A 400-mg dose of the trifluorinated quinolone Ro 23-6240 was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and cantharidin-induced inflammatory fluid were measured. Absorption was rapid, with a mean peak level in serum of 6.1 micrograms/ml, which was attained 0.71 h after administration. The elimination half-life in serum was 11.95 h. The agent penetrated the inflammatory fluid rapidly; the percent penetration was 89.7%. Urinary recovery of Ro 23-6240 was 58.6% by 72 h.

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