Open AccessSusceptibility of Nocardia asteroides to new quinolones and beta-lactams
Author(s) -
Myles E. Gombert,
T M Aulicino,
L duBouchet,
L R Berkowitz
Publication year - 1987
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.31.12.2013
Subject(s) - nocardia , agar dilution , cefpirome , amikacin , minocycline , imipenem , cephalosporin , microbiology and biotechnology , ciprofloxacin , antibacterial agent , ceftriaxone , antibiotics , chemistry , medicine , biology , minimum inhibitory concentration , bacteria , antibiotic resistance , genetics
The susceptibility of 31 strains of Nocardia asteroides to various quinolones and beta-lactams, as well as coumermycin, amikacin, and minocycline, was determined by the agar dilution technique. Ciprofloxacin was the most active fluoroquinolone tested on a weight basis, as it inhibited approximately 50% of the isolates at achievable drug levels in serum. Ceftriaxone and cefpirome were the most active cephalosporins in this system with MICs of 8 micrograms/ml for 80% of strains tested. Imipenem, amikacin, and minocycline were the most effective agents tested.
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