Open AccessNorfloxacin resistance in a clinical isolate of Escherichia coli
Author(s) -
Hiroshi Aoyama,
Kenichi Sato,
Takayuki Kato,
Keiji Hirai,
S Mitsuhashi
Publication year - 1987
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.31.10.1640
Subject(s) - norfloxacin , escherichia coli , dna gyrase , microbiology and biotechnology , dna supercoil , drug resistance , enterobacteriaceae , biology , antibiotics , dna , ciprofloxacin , gene , genetics , dna replication
Analysis of DNA gyrase supercoiling and of norfloxacin uptake in Escherichia coli GN14176, a moderately norfloxacin-resistant clinical isolate, indicated that resistance was associated with both an altered drug target and a reduction in drug uptake.
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