Effect of oral ofloxacin on fecal bacteria in human volunteers | Zendy

Sophie Pecquet | Zendy; Antoine Andremont | Zendy; C Tancrède | Zendy

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Effect of oral ofloxacin on fecal bacteria in human volunteers

Author(s) -

Sophie Pecquet,

Antoine Andremont,

C Tancrède

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.1.124

Subject(s) - ofloxacin , enterobacteriaceae , microbiology and biotechnology , feces , colonization , anaerobic bacteria , bacteria , antibacterial agent , biology , flora (microbiology) , medicine , antibiotics , ciprofloxacin , escherichia coli , biochemistry , genetics , gene

Intestinal members of the family Enterobacteriaceae were eliminated in five human volunteers treated with oral ofloxacin for 5 days. No emergence of resistant Enterobacteriaceae was observed. Counts of group D streptococci were significantly reduced. Colonization by Candida sp. was observed in all five volunteers during ofloxacin treatment. The anaerobic flora was fairly stable from one sample to another before treatment and was not substantially modified by ofloxacin.

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