Early effects of beta-lactams on aminoglycoside uptake, bactericidal rates, and turbidimetrically measured growth inhibition in Pseudomonas aeruginosa | Zendy

Michael H. Miller | Zendy; Stuart A. Feinstein | Zendy; R T Chow | Zendy

Open Access

Early effects of beta-lactams on aminoglycoside uptake, bactericidal rates, and turbidimetrically measured growth inhibition in Pseudomonas aeruginosa

Author(s) -

Michael H. Miller,

Stuart A. Feinstein,

R T Chow

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.1.108

Subject(s) - tobramycin , aminoglycoside , cefsulodin , pseudomonas aeruginosa , microbiology and biotechnology , gentamicin , escherichia coli , antibacterial agent , antibiotics , pseudomonadaceae , biology , pseudomonas , chemistry , bacteria , biochemistry , piperacillin , genetics , gene

In vitro studies of tircarcillin or cefsulodin combined with [3H]tobramycin were performed with Pseudomonas aeruginosa. The rate of bacterial killing, the uptake of tobramycin, and the effects on optical density were measured. Both beta-lactams increased the uptake of subinhibitory concentrations of tobramycin. This result was quantitatively associated with a 2- to 4-h time-kill potentiation and confirmed earlier studies on the mechanism of beta-lactam-aminoglycoside synergy in Escherichia coli (P. H. Plotz and B. D. Davis, Science 135:1067-1068, 1962).

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