In vitro susceptibility of gram-positive cocci to paldimycin | Zendy

D J Pohlod | Zendy; Louis D. Saravolatz | Zendy; Margaret M. Somerville | Zendy

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In vitro susceptibility of gram-positive cocci to paldimycin

Author(s) -

D J Pohlod,

Louis D. Saravolatz,

Margaret M. Somerville

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.1.104

Subject(s) - gram positive cocci , microbiology and biotechnology , gram , biology , gram positive bacteria , antimicrobial , vancomycin , bacteria , staphylococcus aureus , genetics

Paldimycin (U-70138F) is a new antimicrobial agent with activity against gram-positive cocci. Clinical isolates of staphylococci and streptococci were tested. MICs were higher in Mueller-Hinton broth than in nutrient broth. Change in pH had minimal effect on the MICs in either broth. When inoculum size was varied, an inoculum effect was observed. The gram-positive cocci tested were generally more susceptible to paldimycin than to vancomycin.

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