Bioassay for SF 86-327, a new antifungal agent | Zendy

V L Kan | Zendy; David K. Henderson | Zendy; John E. Bennett | Zendy

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Bioassay for SF 86-327, a new antifungal agent

Author(s) -

V L Kan,

David K. Henderson,

John E. Bennett

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.30.4.628

Subject(s) - bioassay , trichophyton , antifungal , allylamine , pharmacokinetics , trichophyton rubrum , pharmacology , antifungal drug , serum concentration , chromatography , chemistry , biology , medicine , microbiology and biotechnology , genetics , polyelectrolyte , organic chemistry , polymer

A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.

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