Aztreonam concentrations in human tissues obtained during thoracic and gynecologic surgery | Zendy

Thomas R. Beam | Zendy; Rudolph P. Galask | Zendy; Lawrence Friedhoff | Zendy; T. B. Platt | Zendy; M A Leitz | Zendy

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Aztreonam concentrations in human tissues obtained during thoracic and gynecologic surgery

Author(s) -

Thomas R. Beam,

Rudolph P. Galask,

Lawrence Friedhoff,

T. B. Platt,

M A Leitz

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.30.3.505

Subject(s) - aztreonam , fallopian tube , ovary , microgram , medicine , endometrium , surgery , biology , microbiology and biotechnology , in vitro , antibiotics , biochemistry , antibiotic resistance , imipenem

The concentrations of aztreonam in human tissues obtained during surgery were measured after a single 2-g intravenous dose. The average concentration in the skeletal muscle, atrial appendage, lung, sternum, pericardial fluid, endometrium, myometrium, fallopian tube, and ovary varied from 3 to 33 micrograms/g (or microgram/ml). These concentrations significantly exceed the MIC for 90% of strains for most members of the family Enterobacteriaceae.

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