Lack of antibacterial activity of pentoxifylline | Zendy

P K Yu | Zendy; John A. Washington | Zendy

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Lack of antibacterial activity of pentoxifylline

Author(s) -

P K Yu,

John A. Washington

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.30.1.170

Subject(s) - pentoxifylline , escherichia coli , microbiology and biotechnology , antibiotics , antibacterial activity , erythromycin , vancomycin , antibacterial agent , pharmacology , bacteria , medicine , biology , chemistry , staphylococcus aureus , biochemistry , genetics , gene

Pentoxifylline was inactive when tested against 70 fresh clinical bacterial isolates, as well as when tested alone and in combination with erythromycin, vancomycin, or rifampin against Escherichia coli PC1349 (wild type) and its heptose-deficient outer membrane mutant E. coli PC2040. No antibacterial activity of pentoxifylline or its metabolites could be detected in sera from patients receiving pentoxifylline or its metabolites could be detected in sera from patients receiving pentoxifylline.

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