Open AccessBL-20803, a New, Low-Molecular-Weight Interferon Inducer
Author(s) -
Paul Siminoff,
Anthony M. Bernard,
Valentina S. Hursky,
K. E. Price
Publication year - 1973
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.3.6.742
Subject(s) - interferon , vaccinia , dosing , inducer , virus , pharmacology , virology , drug , medicine , immunology , biology , recombinant dna , biochemistry , gene
BL-20803 induced interferon in mice when administered via oral or parenteral routes. During multiple dosing with the drug at 48-h intervals, animals exhibited a hyporesponsive state to the third treatment. Inhibition of vaccinia virus infection was correlated with interferon induction.
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