Open AccessTetracyclines and Host-Defense Mechanisms
Author(s) -
Arne Forsgren,
Håkan Gnarpe
Publication year - 1973
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.3.6.711
Subject(s) - phagocytosis , antibody opsonization , doxycycline , microbiology and biotechnology , intracellular , escherichia coli , bacteria , antibiotics , intracellular parasite , chemistry , minocycline , opsonin , biology , biochemistry , genetics , gene
The effects of different tetracyclines on the bactericidal action of serum and on phagocytosis and intracellular killing of bacteria were investigated. Opsonization, phagocytosis, and intracellular killing were not significantly affected by any of the investigated tetracyclines. The bactericidal action of serum onEscherichia coli was substantially reduced by all tetracyclines investigated. In this respect, doxycycline had a much more pronounced action than the other tetracyclines. The serum bactericidal effect could be completely restored by addition of Mg2+ .