Open AccessAntiviral Activity of Tobacco Smoke Condensate on Encephalomyocarditis Infection in Mice
Author(s) -
Eiichi Furusawa,
S. Ramanathan,
Naoki Suzuki,
Satoru Tani,
Shinobu Furusawa
Publication year - 1973
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.3.4.484
Subject(s) - vesicular stomatitis virus , virus , vaccinia , virology , tobacco smoke , interferon , biology , microbiology and biotechnology , chemistry , biochemistry , gene , recombinant dna , polymer chemistry
A water-soluble nontumorigenic acidic fraction of tobacco smoke condensate of cigarettes has been found to have antiviral activity against encephalomyocarditis (EMC) virus infection in mice. The portion of lower molecular weight was inhibitory to the growth of EMC virus, vesicular stomatitis virus, reovirus type 2, vaccinia virus, and poliovirus type 2, but not against adenovirus type 12, in KB cell cultures. The cigarette smoke agent did not induce serum interferon although it protected mice from EMC disease by pretreatment.