Two Enzymes Which Phosphorylate Neomycin and Kanamycin in Escherichia coli Strains Carrying R Factors | Zendy

Maria Swiontek Brzezinska | Zendy; Julian Davies | Zendy

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Two Enzymes Which Phosphorylate Neomycin and Kanamycin in Escherichia coli Strains Carrying R Factors

Author(s) -

Maria Swiontek Brzezinska,

Julian Davies

Publication year - 1973

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.3.2.266

Subject(s) - kanamycin , neomycin , phosphotransferase , escherichia coli , phosphorylation , biology , enzyme , antibiotics , biochemistry , microbiology and biotechnology , chemistry , gene

Two enzymes which phosphorylate neomycin and kanamycin have been detected in Escherichia coli strains carrying R factors. Neomycin-kanamycin phosphotransferase I can phosphorylate neomycin and kanamycin, but not butirosin. Neomycin-kanamycin phosphotransferase II can phosphorylate all three antibiotics. The enzymes also differ in their response to certain inhibitors of phosphorylation. Neomycin-kanamycin phosphotransferase II is found in certain strains of Pseudomonas aeruginosa.

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