Open AccessTobramycin and Gentamicin Concentrations in the Serum of Normal and Anephric Patients
Author(s) -
W. R. Lockwood,
John D. Bower
Publication year - 1973
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.3.1.125
Subject(s) - gentamicin , tobramycin , medicine , aminoglycoside , renal function , urology , serum concentration , dialysis , endocrinology , antibiotics , chemistry , biochemistry
The serum half-life of tobramycin was found to be the same as that of gentamicin in patients with similar renal function. The values ranged from 2 hr in normal volunteers to 53.4 hr in anephric patients. Both drugs were readily removed from the serum by the Kiil artificial kidney, with a 70% reduction in serum concentrations during a 12-hr dialysis period.
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