Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases | Zendy

Ludwig Gutmann | Zendy; M Kitzis | Zendy; Shigeru Yamabe | Zendy; J. F. Acar | Zendy

Open Access

Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases

Author(s) -

Ludwig Gutmann,

M Kitzis,

Shigeru Yamabe,

J. F. Acar

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.5.955

Subject(s) - carbenicillin , enterobacter cloacae , citrobacter freundii , clavulanic acid , sulbactam , microbiology and biotechnology , beta lactamase inhibitors , ampicillin , antibiotics , beta lactamase , biology , enterobacter , citrobacter , enterobacteriaceae , chemistry , amoxicillin , escherichia coli , antibiotic resistance , biochemistry , imipenem , gene

YTR 830, a new beta-lactamase inhibitor, combined with amoxicillin or carbenicillin, showed a synergistic effect similar to that observed with clavulanic acid, and generally better than that with sulbactam, against strains harboring chromosome-encoded penicillinases and broad-spectrum beta-lactamases or plasmid-determined beta-lactamases. With ampicillin, YTR 830 showed the best synergistic activity of the inhibitors against Proteus morganii, Citrobacter freundii, and Enterobacter cloacae and their mutants with a derepressed chromosome-encoded cephalosporinase.

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