Open AccessPharmacokinetic study of lenampicillin (KBT-1585) in healthy volunteers
Author(s) -
Akira Saito,
Makoto Nakashima
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.5.948
Subject(s) - ampicillin , pharmacokinetics , oral administration , serum concentration , pharmacology , chemistry , medicine , antibiotics , chromatography , biochemistry
The pharmacokinetic properties of lenampicillin (KBT-1585), a new ampicillin ester, were investigated in 41 healthy volunteers. The maximum concentration of ampicillin in serum after oral administration of 400 mg of lenampicillin was 6.5 micrograms/ml at 0.70 h, and that after a equimolar dosage of ampicillin was 2.9 micrograms/ml at 0.87 h.
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