Open AccessInhibition of herpes simplex virus type 1 replication by halothane
Author(s) -
Elliott Bedows,
Thomas C. Holland,
Paul R. Knight
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.5.941
Subject(s) - vero cell , herpes simplex virus , halothane , virology , hsl and hsv , viral replication , simplexvirus , virus , dna synthesis , herpesviridae , dna , biology , chemistry , viral disease , biochemistry , organic chemistry
Halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) inhibited herpes simplex virus type 1 (HSV-1) replication, although HSV-1 DNA was synthesized at normal levels in Vero cells. Viral capsids and extracellular virions were inhibited, and HSV-1 protein synthesis decreased by 50%, although no specific HSV-1 protein failed to be synthesized. Hyperbaric pressure failed to reverse the halothane-induced inhibition of HSV-1 replication.