Open AccessSensitivity of Candida albicans to amphotericin B administered as single or fractionated doses
Author(s) -
Marcia L. Sokol-Anderson,
J Brajtburg,
Gerald Medoff
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.4.701
Subject(s) - candida albicans , amphotericin b , corpus albicans , pharmacology , microbiology and biotechnology , toxicity , medicine , biology , chemistry , antifungal
Candida albicans cells were exposed to equal concentrations of amphotericin B (AmB) administered either as a single large dose or as repeated small doses. Toxicity to C. albicans cells was less pronounced when AmB was administered in fractionated doses. Increased catalase activity in C. albicans cells was induced after exposure to fractionated doses of AmB; this increase may have contributed to the greater resistance of cells to AmB used according to this schedule.