Plasmid-mediated high-level resistance to erythromycin in Escherichia coli | Zendy

Antoine Andremont | Zendy; G Gerbaud | Zendy; Patrice Courvalin | Zendy

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Plasmid-mediated high-level resistance to erythromycin in Escherichia coli

Author(s) -

Antoine Andremont,

G Gerbaud,

Patrice Courvalin

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.3.515

Subject(s) - erythromycin , escherichia coli , plasmid , microbiology and biotechnology , esterase , biology , antibiotics , enterobacteriaceae , antibiotic resistance , gene , strain (injury) , genetics , enzyme , biochemistry , anatomy

Escherichia coli BM2195 was found to be resistant to high levels of erythromycin. This new resistance phenotype was due to the constitutive synthesis of an erythromycin esterase which inactivates the antibiotic. The gene conferring resistance to erythromycin in this strain is carried on a 61-kilobase self-transferable plasmid, pIP1100, belonging to incompatibility group X.

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