Comparative in vitro antimicrobial activity of carumonam, a new monocyclic beta-lactam | Zendy

B R Smith | Zendy; Jack L. LeFrock | Zendy; R. V. McCloskey | Zendy; J B Donato | Zendy; Scott Weber | Zendy; Warren S. Joseph | Zendy

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Comparative in vitro antimicrobial activity of carumonam, a new monocyclic beta-lactam

Author(s) -

B R Smith,

Jack L. LeFrock,

R. V. McCloskey,

J B Donato,

Scott Weber,

Warren S. Joseph

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.2.346

Subject(s) - aztreonam , ceftazidime , piperacillin , cefoperazone , cefotaxime , microbiology and biotechnology , antimicrobial , gentamicin , cefsulodin , antibiotics , chemistry , pseudomonas aeruginosa , biology , imipenem , bacteria , antibiotic resistance , genetics

The antimicrobial activity of carumonam (formerly RO-17-2301), a monocyclic beta-lactam antibiotic, was compared with those of aztreonam, cefotaxime, cefoperazone, ceftazidime, piperacillin, and gentamicin against 455 bacterial isolates. Carumonam did not possess activity against gram-positive cocci and was generally comparable to aztreonam and ceftazidime for most gram-negative bacilli. However, carumonam was the most active beta-lactam against gentamicin-resistant Pseudomonas aeruginosa strains (90% MIC, 8 micrograms/ml).

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