Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation | Zendy

S Gollapudi | Zendy; Rao Prabhala | Zendy; H Thadepalli | Zendy

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Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation

Author(s) -

S Gollapudi,

Rao Prabhala,

H Thadepalli

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.2.337

Subject(s) - concanavalin a , splenocyte , peripheral blood mononuclear cell , thymidine , ciprofloxacin , cell growth , lymphocyte , immunology , pharmacology , biology , chemistry , endocrinology , medicine , in vitro , microbiology and biotechnology , immune system , biochemistry , antibiotics

Ciprofloxacin was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohemagglutinin-stimulated proliferation (measured by [3H]thymidine uptake) of human peripheral blood mononuclear cells and murine splenocytes. Ciprofloxacin did not diminish or enhance mononuclear cell proliferation at concentrations of 5 to 125 micrograms/ml. Further, the proliferative response of splenocytes of mice previously treated with ciprofloxacin (40 mg/kg, twice daily for 5 days) was essentially similar to that of untreated controls.

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