Acyclic guanosine analogs as substrates for varicella-zoster virus thymidine kinase | Zendy

Anders R. Karlström | Zendy; Clas F. R. Källander | Zendy; G Abele | Zendy; AnnaKarin Larsson | Zendy

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Acyclic guanosine analogs as substrates for varicella-zoster virus thymidine kinase

Author(s) -

Anders R. Karlström,

Clas F. R. Källander,

G Abele,

AnnaKarin Larsson

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.1.171

Subject(s) - guanine , thymidine kinase , guanosine , thymidine , varicella zoster virus , enzyme , biology , biochemistry , chemistry , guanosine diphosphate , virus , microbiology and biotechnology , nucleotide , virology , dna , herpes simplex virus , gene

This study was performed to obtain information on the enzymatic background to the antiviral activity of acyclic guanosine analogs. Five acyclic guanosine analogs, the (R)- and (S)-enantiomers of 9-(3,4-dihydroxybutyl)guanine, 9-(4-hydroxybutyl)guanine, 9-[(2-hydroxyethoxy)methyl]guanine, and 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine, were compared in enzyme kinetic experiments using purified varicella-zoster virus and human placenta mitochondrial thymidine kinase (TK). All analogs showed competitive patterns of inhibition in the phosphorylation of thymidine by varicella-zoster virus TK, but only low affinities and phosphorylation rates were observed. No affinity for the mitochondrial TK was observed for any of the analogs.

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