Synthesis and antibacterial activities of optically active ofloxacin | Zendy

I Hayakawa | Zendy; S. ATARASHI | Zendy; S. YOKOHAMA | Zendy; Masako Imamura | Zendy; Katsu-ichi Sakano | Zendy; Mutsumi Furukawa | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis and antibacterial activities of optically active ofloxacin

Author(s) -

I Hayakawa,

S. ATARASHI,

S. YOKOHAMA,

Masako Imamura,

Katsu-ichi Sakano,

Mutsumi Furukawa

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.1.163

Subject(s) - ofloxacin , enantiomer , optically active , chemistry , antibacterial agent , stereochemistry , organic chemistry , antibiotics , biochemistry , ciprofloxacin

Two optically active (100% enantiomeric excess) isomers of ofloxacin [(+/-)-ofloxacin; DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid] were prepared by use of their optically resolved synthetic intermediates. One of the isomers, (-)-ofloxacin, was 8 to 128 times more potent in inhibiting the multiplication of gram-positive and gram-negative bacteria than the other, (+)-ofloxacin, and approximately two times more active than the racemate, (+/-)-ofloxacin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research