Open AccessNorfloxacin penetration into human renal and prostatic tissues
Author(s) -
Michel G. Bergeron,
M. Thabet,
R Roy,
C Lessard,
P Foucault
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.28.2.349
Subject(s) - norfloxacin , prostate , kidney , urinary system , genitourinary system , urology , urine , pharmacokinetics , medicine , biology , antibiotics , microbiology and biotechnology , ciprofloxacin , cancer
Concurrent norfloxacin concentrations in serum, kidney, and prostatic tissue were determined in 14 patients. Mean ratios of norfloxacin concentration in tissue over concentration in serum were 6.6 +/- 2.8 for the kidney and 1.7 +/- 0.2 for the prostate samples. The levels were above the MICs of most urinary pathogens.
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