Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis | Zendy

Connie Whiteside Yim | Zendy; Neil M. Flynn | Zendy; Felicity Fitzgerald | Zendy

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Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis

Author(s) -

Connie Whiteside Yim,

Neil M. Flynn,

Felicity Fitzgerald

Publication year - 1985

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.28.2.347

Subject(s) - doxycycline , neurosyphilis , cerebrospinal fluid , medicine , penicillin , regimen , antibiotics , penetration (warfare) , csf albumin , gastroenterology , pharmacology , syphilis , immunology , chemistry , biochemistry , operations research , human immunodeficiency virus (hiv) , engineering

Five patients with laboratory evidence of latent or neurosyphilis were treated orally with doxycycline (200 mg) twice a day for 21 days. After the seventh dose, the mean level of doxycycline in serum was 5.8 micrograms/ml, with a mean drug level in cerebrospinal fluid of 1.3 micrograms/ml. The mean penetration into cerebrospinal fluid was 26%. These preliminary findings suggest that doxycycline, administered orally at a dose of 200 mg twice a day, reaches a sufficient concentration in cerebrospinal fluid to be worthy of further evaluation as an alternative regimen to penicillin therapy for latent or neurosyphilis.

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