Open AccessSelf-induced nystatin resistance in Dictyostelium discoideum
Author(s) -
Durgadas P. Kasbekar,
Sanford J. Madigan,
Eugene R. Katz
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.6.974
Subject(s) - dictyostelium discoideum , nystatin , polyene , slime mold , microbiology and biotechnology , biology , natamycin , antibiotics , biochemistry , food science , gene
The cellular slime mold Dictyostelium discoideum is normally susceptible to the action of the polyene antibiotic nystatin. We describe conditions under which transient nystatin resistance can be induced in the absence of detectable changes in sterol composition. These results suggest that nystatin plays a positive role in promoting resistance to itself.
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